HPVomics

A therapeutic and epitome resource for Human Papillomaviruses

Efficient putative HR-HPVs E1^E4 protein epitopes (MHC-II Binders)


S.No. HPV type Target region Peptide seuences Start End Allele Method Percentile rank
1 HPV58 E1^E4 DPEVIKYPLLKLLTQ 3 17 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.07
2 HPV58 E1^E4 PEVIKYPLLKLLTQR 4 18 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.08
3 HPV58 E1^E4 DDPEVIKYPLLKLLT 2 16 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.11
4 HPV66 E1^E4 DTTYPLLRLLTNTTT 9 23 HLA-DRB1*04:01 Consensus 0.11
5 HPV66 E1^E4 TTYPLLRLLTNTTTT 10 24 HLA-DRB1*04:01 Consensus 0.11
6 HPV66 E1^E4 TYPLLRLLTNTTTTG 11 25 HLA-DRB1*04:01 Consensus 0.11
7 HPV66 E1^E4 YPLLRLLTNTTTTGP 12 26 HLA-DRB1*04:01 Consensus 0.11
8 HPV58 E1^E4 EVIKYPLLKLLTQRP 5 19 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.13
9 HPV56 E1^E4 TYPLLKLLTNTTPTR 11 25 HLA-DRB1*04:01 Consensus 0.17
10 HPV82 E1^E4 PRHPLLQLLNSYRTP 9 23 HLA-DRB1*15:01 Consensus 0.17
11 HPV53 E1^E4 TYPLLKLLTNTTPIR 11 25 HLA-DRB1*04:01 Consensus 0.18
12 HPV53 E1^E4 YPLLKLLTNTTPIRP 12 26 HLA-DRB1*04:01 Consensus 0.18
13 HPV56 E1^E4 YPLLKLLTNTTPTRP 12 26 HLA-DRB1*04:01 Consensus 0.18
14 HPV82 E1^E4 RHPLLQLLNSYRTPP 10 24 HLA-DRB1*15:01 Consensus 0.18
15 HPV82 E1^E4 APRHPLLQLLNSYRT 8 22 HLA-DRB1*15:01 Consensus 0.19
16 HPV58 E1^E4 MDDPEVIKYPLLKLL 1 15 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.2
17 HPV66 E1^E4 DTTYPLLRLLTNTTT 9 23 HLA-DRB1*04:05 Consensus 0.21
18 HPV66 E1^E4 TTYPLLRLLTNTTTT 10 24 HLA-DRB1*04:05 Consensus 0.21
19 HPV66 E1^E4 TYPLLRLLTNTTTTG 11 25 HLA-DRB1*04:05 Consensus 0.21
20 HPV66 E1^E4 YPLLRLLTNTTTTGP 12 26 HLA-DRB1*04:05 Consensus 0.21
21 HPV58 E1^E4 DPEVIKYPLLKLLTQ 3 17 HLA-DPA1*02:01/DPB1*01:01 Consensus 0.23
22 HPV66 E1^E4 PLLRLLTNTTTTGPP 13 27 HLA-DRB1*04:01 Consensus 0.23
23 HPV18 E1^E4 TTRYPLLSLLNSYST 9 23 HLA-DRB1*04:05 Consensus 0.25
24 HPV58 E1^E4 PEVIKYPLLKLLTQR 4 18 HLA-DPA1*02:01/DPB1*01:01 Consensus 0.25
25 HPV18 E1^E4 VTTRYPLLSLLNSYS 8 22 HLA-DRB1*04:05 Consensus 0.26
26 HPV18 E1^E4 TRYPLLSLLNSYSTP 10 24 HLA-DRB1*04:05 Consensus 0.26
27 HPV53 E1^E4 PTYPLLKLLTNTTPI 10 24 HLA-DRB1*04:01 Consensus 0.26
28 HPV82 E1^E4 HPLLQLLNSYRTPPR 11 25 HLA-DRB1*15:01 Consensus 0.26
29 HPV18 E1^E4 RYPLLSLLNSYSTPP 11 25 HLA-DRB1*04:05 Consensus 0.27
30 HPV56 E1^E4 TTYPLLKLLTNTTPT 10 24 HLA-DRB1*04:01 Consensus 0.27
31 HPV58 E1^E4 DDPEVIKYPLLKLLT 2 16 HLA-DPA1*02:01/DPB1*01:01 Consensus 0.27
32 HPV18 E1^E4 YPLLSLLNSYSTPPH 12 26 HLA-DRB1*04:05 Consensus 0.28
33 HPV52 E1^E4 EVTKYPLLKLLSTYA 5 19 HLA-DRB1*15:01 Consensus 0.32
34 HPV52 E1^E4 VTKYPLLKLLSTYAP 6 20 HLA-DRB1*15:01 Consensus 0.32
35 HPV52 E1^E4 TKYPLLKLLSTYAPK 7 21 HLA-DRB1*15:01 Consensus 0.33
36 HPV52 E1^E4 KYPLLKLLSTYAPKP 8 22 HLA-DRB1*15:01 Consensus 0.34
37 HPV52 E1^E4 YPLLKLLSTYAPKPP 9 23 HLA-DRB1*15:01 Consensus 0.35
38 HPV58 E1^E4 EVIKYPLLKLLTQRP 5 19 HLA-DPA1*02:01/DPB1*01:01 Consensus 0.38
39 HPV82 E1^E4 PLLQLLNSYRTPPRP 12 26 HLA-DRB1*15:01 Consensus 0.41
40 HPV58 E1^E4 MDDPEVIKYPLLKLL 1 15 HLA-DPA1*02:01/DPB1*01:01 Consensus 0.43
41 HPV59 E1^E4 TSKYPLLDLLSNYHT 9 23 HLA-DRB1*15:01 Consensus 0.43
42 HPV59 E1^E4 KYPLLDLLSNYHTPP 11 25 HLA-DRB1*15:01 Consensus 0.43
43 HPV59 E1^E4 YPLLDLLSNYHTPPQ 12 26 HLA-DRB1*15:01 Consensus 0.43
44 HPV66 E1^E4 VDTTYPLLRLLTNTT 8 22 HLA-DRB1*04:05 Consensus 0.43
45 HPV53 E1^E4 DPTYPLLKLLTNTTP 9 23 HLA-DRB1*04:01 Consensus 0.45
46 HPV56 E1^E4 DTTYPLLKLLTNTTP 9 23 HLA-DRB1*04:01 Consensus 0.45
47 HPV53 E1^E4 PTYPLLKLLTNTTPI 10 24 HLA-DRB1*04:05 Consensus 0.54
48 HPV53 E1^E4 TYPLLKLLTNTTPIR 11 25 HLA-DRB1*04:05 Consensus 0.55
49 HPV56 E1^E4 TTYPLLKLLTNTTPT 10 24 HLA-DRB1*04:05 Consensus 0.55
50 HPV68 E1^E4 TEKYPLLNLLPTYRT 9 23 HLA-DRB5*01:01 Consensus 0.55
51 HPV53 E1^E4 DPTYPLLKLLTNTTP 9 23 HLA-DRB1*04:05 Consensus 0.58
52 HPV53 E1^E4 YPLLKLLTNTTPIRP 12 26 HLA-DRB1*04:05 Consensus 0.58
53 HPV56 E1^E4 TYPLLKLLTNTTPTR 11 25 HLA-DRB1*04:05 Consensus 0.58
54 HPV66 E1^E4 VDTTYPLLRLLTNTT 8 22 HLA-DRB1*04:01 Consensus 0.58
55 HPV56 E1^E4 DTTYPLLKLLTNTTP 9 23 HLA-DRB1*04:05 Consensus 0.59
56 HPV56 E1^E4 YPLLKLLTNTTPTRP 12 26 HLA-DRB1*04:05 Consensus 0.66
57 HPV53 E1^E4 LDPTYPLLKLLTNTT 8 22 HLA-DRB1*04:05 Consensus 0.94
58 HPV56 E1^E4 VDTTYPLLKLLTNTT 8 22 HLA-DRB1*04:05 Consensus 0.94
59 HPV66 E1^E4 TYPLLRLLTNTTTTG 11 25 HLA-DRB1*01:01 Consensus 0.97
60 HPV33 E1^E4 ATKYPLLKLLTYRQT 6 20 HLA-DPA1*02:01/DPB1*14:01 NetMHCIIpan 0.96
61 HPV33 E1^E4 KYPLLKLLTYRQTTI 8 22 HLA-DPA1*02:01/DPB1*14:01 NetMHCIIpan 0.97
62 HPV33 E1^E4 TKYPLLKLLTYRQTT 7 21 HLA-DPA1*02:01/DPB1*14:01 NetMHCIIpan 1